Connexin gap junctions play an important role in hearing function, but the mechanism by
which this contribution occurs is unknown. Connexins in the cochlea are expressed only in …

Gap junctions play a critical role in hearing and mutations in connexin genes cause a high
incidence of human deafness. Pathogenesis mainly occurs in the cochlea, where gap …

Several different recessive mutations in the connexin26 (Cx26; β2) gene have been
associated with non‐syndromic hereditary deafness. This suggests gap junctions are …

Mutations in the genes encoding for gap junction proteins connexin 26 (Cx26) and connexin
30 (Cx30) have been linked to syndromic and nonsyndromic hearing loss in mice and …

Gap junctional intercellular communication (GJIC) plays a major role in cochlear function.
Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent …

Normal development, function and repair of the sensory epithelia in the inner ear are all
dependent on gap junctional intercellular communication. Mutations in the connexin genes …

Despite recent advances, a better understanding of the complexity of gap-junctional
communication in the inner ear and the structure–function relationships of connexin proteins …

Extracellular ATP controls various signaling systems including propagation of intercellular
Ca2+ signals (ICS). Connexin hemichannels, P2x7 receptors (P2x7Rs), pannexin channels …

Mammalian hearing relies upon active cochlear mechanics, which arises from outer hair cell
electromotility and hair bundle movement, to amplify acoustic stimulations increasing …

A gap junction is composed of two hemichannels and possesses a relatively large pore size
(∼ 10–15 Å), allowing passage of ions and molecules up to 1 kDa. Here, we report that …