Cancers develop through a process called genomic instability, which generates diversity,
from which clonal evolution may occur. In colorectal cancers, this process has been …

Colorectal cancer is characterized by exquisite genomic instability either in the form of
microsatellite instability or chromosomal instability. Microsatellite instability is the result of …

Colorectal cancer is the end result of an accumulation of destabilizing mutations and other
genetic events, which occur in clones of colonocytes over many years. While each colorectal …

The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Most of the colorectal cancer (CRC) cases are sporadic, only 25% of the patients have a
family history of the disease, and major genes causing syndromes predisposing to CRC only …

Neoplastic transformation is increasingly understood in terms of evolutionary mechanisms,
and it is now widely accepted that tumor progression involves natural selection of genetic …

We hypothesized that in a comprehensive analysis of colorectal carcinomas (CRC) the three
currently known major molecular mechanisms of carcinogenesis (ie, chromosomal …

Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

Colon cancer is the second most lethal cancer; approximately 600,000 people die of it
annually in the world. Colon carcinogenesis generally follows a slow and stepwise process …