Abstract The BRAF V600E mutation has been associated with microsatellite instability and
the CpG island methylator phenotype (CIMP) in colon cancer. We evaluated a large …

Background: Cigarette smoking has been associated with microsatellite instability in
sporadic colon cancer. Most microsatellite-unstable colon cancers have widespread …

Context.—The 2 chief pathways implicated in colorectal carcinogenesis, microsatellite
instability and chromosomal instability, are not present in 20% to 37% of cases. Objective …

The association of BRAF V600E mutation and the presence of the CpG island methylator
phenotype (CIMP) and microsatellite instability (MSI) often confound analysis of BRAF …

BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through
its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter …

Background: The objective of the study was to examine the role of microsatellite instability
(MSI) and BRAF V600E mutation in colorectal cancer (CRC) by categorising patients into …

Mucinous colorectal cancer (CRC) has been reported to have distinct clinicopathological
and genetic characteristics. However, the incidence and the relationship among …

We have identified an alternative pathway of tumorigenesis in sporadic colon cancer,
involving microsatellite instability due to mismatched repair methylation, which may be …

An important proportion of early-onset colorectal cancer (CRC) does not show a hereditary
component with limited knowledge about its molecular basis and features. We analyzed a …

The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating
V600E mutation occurs in 15% of sporadic colorectal cancer. This is an early event in …