Previous work has shown that endothelial cell (EC)-derived matrix metalloproteinases
(MMPs) regulate regression of capillary tubes in vitro in a plasmin-and MMP-1 dependent …

Here, we describe a new function for plasmin and matrix metalloproteinases (MMPs), which
is to regulate the regression of capillary tubes in three-dimensional extracellular matrix …

In this review, we discuss the identification of distinct matrix metalloproteinases (MMPs) and
their inhibitors that differentially control the processes of capillary tube formation …

During angiogenesis, endothelial cells (ECs) degrade their surrounding extracellular matrix
(ECM) to facilitate invasion. How interactions between ECs and other cells within their …

Pericellular degradation of interstitial collagens is a crucial event for cells to migrate through
the dense connective tissue matrices, where collagens exist as insoluble fibers. A key …

Fibroblasts degrade type I collagen, the major extracellular protein found in mammals,
during events ranging from bulk tissue resorption to invasion through the three-dimensional …

The vascular endothelium continually senses and responds to biochemical and mechanical
stimuli to appropriately initiate angiogenesis. We have shown previously that fluid wall shear …

Acute and chronic injuries are characterized by leukocyte infiltration into tissues. Although
matrix metalloproteinase 9 (Mmp9) has been implicated in both conditions, its role in wound …

We have performed a screening analysis of differential gene expression using a defined in
vitro model of human capillary tube formation. Gene array, differential display and cDNA …

To gain insight into how a naturally occurring scaffold composed of extracellular matrix
(ECM) proteins provides directional guidance for capillary sprouting, we examined …