Background—The early inflammatory response during reperfusion of cardiac allografts is
initiated by the infiltration of polymorphonuclear leukocytes (PMNs) into the graft. The impact …

Building on studies showing that ischemia–reperfusion-(I/R)-injury is complement
dependent, we tested links among complement activation, transplantation-associated I/R …

The pathogenic role of macrophages in antibody-mediated rejection (AMR) remains unclear.
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic factor for …

The early inflammatory response within organ allografts is initiated by ischemia/reperfusion
(I/R) and promotes subsequent alloantigen-primed T cell recruitment into and rejection of the …

Background. Chemokines are well-established to function in the recruitment of leukocytes
into allografts in the course of rejection. Moreover, some studies have indicated that there …

Background. Current immunosuppression regimens are toxic to transplant recipients and, in
many cases, acute rejection episodes occur because of escape of donor-reactive …

Background Chemokines play an essential role in regulating the infiltration of leukocytes
into allografts in experimental models. Little is known of their expression or function after …

Chemokine-chemokine receptor interactions orchestrate mononuclear cells recruitment to
the allograft, leading to acute and chronic rejection. Despite biologic redundancy, several …

Previous studies showed that absence of chemokine receptor Cxcr3 or its blockade prolong
mouse cardiac allograft survival. We evaluated the effect of the CXCR3 receptor antagonist …

To study the role of the direct and indirect pathways in achieving tolerance, we used
genetically altered mouse strains in two ways: 1) MHC class II-deficient mice were used as …