There is a large body of literature showing that prolactin (PRL) exerts growth-promoting
activities in breast cancer, and possibly in prostate cancer and prostate hyperplasia. In …

Prolactin (PRL) promotes tumor growth in various experimental models and leads to
prostate hyperplasia and mammary neoplasia in PRL transgenic mice. Increasing …

Prolactin is a polypeptide hormone whose major biological actions are related to normal
lactation and reproduction. Abnormally high prolactin levels, referred to as …

Introduction: Prolactin (PRL) signaling has emerged as a relevant target in breast and
prostate cancers. This has encouraged various laboratories to develop compounds targeting …

Prolactin (PRL) receptors are expressed in a broad range of human cell types and in a
majority of human breast and prostate cancers. Experimentally, normal and malignant …

Previous studies have demonstrated that naturally phosphorylated PRL antagonizes the
growth-promoting effects of unmodified PRL in two different PRL-responsive cell lines. In this …

Human prolactin (PRL) is currently viewed as a hormone of pituitary origin, whose
production (ie serum levels) is controlled by dopamine, whose biological actions relate …

Based on the assumption that the prolactin receptor (PRLR) is activated by PRL-induced
sequential dimerization, potential human PRL (hPRL) antagonists were designed that …

Breast and prostate cancers are hormone-sensitive malignancies that afflict millions of
women and men. Although prolactin (PRL) is known as a survival factor that supports tumor …

Prolactin (PRL) has a dual function–as a circulating hormone and as a cytokine. This
understanding is based on PRL production and distinct regulation in extrapituitary sites, its …