Purpose: Hereditary nonpolyposis colorectal cancer (HNPCC) is the commonest form of
inherited colorectal cancer. Whereas it has been known that mismatch repair gene …

Purpose Hereditary nonpolyposis colorectal cancer (HNPCC) may be caused by mutations
in mismatch repair (MMR) genes. The aim of this study was to validate …

Genetic diagnosis of hereditary nonpolyposis colorectal cancer (HNPCC) may have a
significant impact on the clinical management of patients and their at‐risk relatives. At …

BACKGROUND Hereditary nonpolyposis colorectal cancer (HNPCC) is linked genetically to
mutations in DNA mismatch repair (MMR) genes. Because a deficiency in MMR does not …

BACKGROUND AND AIMS There are multiple criteria for the clinical diagnosis of hereditary
non-polyposis colorectal cancer (HNPCC). The value of several of the newer proposed …

Hereditary nonpolyposis colorectal cancer (HNPCC) is a multi-organ cancer syndrome
associated with heritable mutations in DNA mismatch repair genes, particularly MLH1 (MutL …

Background: Patients with early-onset colorectal cancer (CRC) or those with multiple
tumours associated with hereditary non-polyposis colorectal cancer (HNPCC) raise …

Purpose: The aim of study was to determine the clinical characteristics and mutational
profiles of the mismatch repair genes in hereditary nonpolyposis colorectal cancer (HNPCC) …

BACKGROUND & AIMS: Germline mutations in four DNA mismatch repair genes are known
to cause susceptibility to hereditary nonpolyposis colorectal cancer (HNPCC). The rapidly …

Introduction: Hereditary non-polyposis colorectal cancer (HNPCC) is a major form of familial
colorectal cancer (CRC). It is diagnosed when either the Amsterdam criteria (AC) are fulfilled …