Another very important factor is the condition of the patient. The myocardium of aged
experimental animals and patients cannot be adequately preconditioned. 6 Exercise, 7 …

For many years, the functional sequelae of chronic coronary artery disease were considered
irreversible and amenable only to palliative therapy. However, towards the end of the 1970s …

Direct clinical evidence for the classical preconditioning phenomenon, with infarct size
limitation as an endpoint, cannot be obtained. However, a number of patient groups have …

Ischemic preconditioning has been shown to be one of the most powerful means of
protecting the myocardium from ischemic injury in experimental animal models, although the …

Ischemic pre-and postconditioning confer powerful protection to the ischemic/reperfused
myocardium. Nevertheless, 25 years after the discovery of preconditioning, we still do not …

The phenomenon of ischaemic preconditioning, highlights a new and endogenous route to
myocardial protection, which we believe could be exploited in our search for new …

Despite thousands of publications describing agents that limit infarct size in animals, all we
have available today is reperfusion therapy. In this review, we examine why these drugs …

The review describes the phenomena of ischemic myocardial preconditioning, conditioning,
and postconditioning, as well as the relevant molecular mechanisms, in patients with …

Myocardial protection aims at preventing myocardial tissue loss:(a) In the acute stage, ie,
during primary angioplasty in acute myocardial infarction. In this setup, the attenuation of …

A mild stress such as brief ischemic episodes may protect the heart from a successive and
more prolonged myocardial ischemia (ischemic preconditioning). This phenomenon is …