'Compulsive'lever pressing in rats is enhanced following lesions to the orbital cortex, but not to the basolateral nucleus of the amygdala or to the dorsal medial …
D Joel, J Doljansky, D Schiller - European Journal of …, 2005 - Wiley Online Library
In a new rat model of obsessive–compulsive disorder (OCD),'compulsive'behaviour is
induced by attenuating a signal indicating that a lever‐press response was effective in …
induced by attenuating a signal indicating that a lever‐press response was effective in …
The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system
EA Schilman, O Klavir, C Winter, R Sohr… - …, 2010 - nature.com
In the signal attenuation rat model of obsessive-compulsive disorder (OCD),'compulsive'
behavior is induced by attenuating a signal indicating that a lever-press response was …
behavior is induced by attenuating a signal indicating that a lever-press response was …
Role of the orbital cortex and of the serotonergic system in a rat model of obsessive compulsive disorder
D Joel, J Doljansky, N Roz, M Rehavi - Neuroscience, 2005 - Elsevier
The serotonergic system and the orbitofrontal cortex have been consistently implicated in
the pathophysiology of obsessive compulsive disorder. Yet, the relations between these two …
the pathophysiology of obsessive compulsive disorder. Yet, the relations between these two …
The effects of temporary inactivation of the orbital cortex in the signal attenuation rat model of obsessive compulsive disorder.
Rats undergoing extinction of lever pressing after an external feedback for this behavior was
attenuated by extinguishing its Pavlovian association with the reward (signal attenuation) …
attenuated by extinguishing its Pavlovian association with the reward (signal attenuation) …
Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?
D Joel, A Avisar - Behavioural brain research, 2001 - Elsevier
This study aimed at developing a rat model of obsessive compulsive disorder based on the
hypothesis that a deficient response feedback mechanism underlies obsessions and …
hypothesis that a deficient response feedback mechanism underlies obsessions and …
The role of the subthalamic nucleus in 'compulsive'behavior in rats
C Winter, S Flash, O Klavir, J Klein… - European Journal of …, 2008 - Wiley Online Library
Different lines of evidence point to dysfunction of basal ganglia‐thalamocortical circuits in
obsessive‐compulsive disorder (OCD). It has been hypothesized that the circuits' …
obsessive‐compulsive disorder (OCD). It has been hypothesized that the circuits' …
'Compulsive'lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or …
D Joel, E Ben-Amir, J Doljansky… - Behavioural …, 2004 - journals.lww.com
Rats undergoing extinction of lever-pressing for food after the attenuation of an external
feedback for this behavior, exhibit excessive lever-pressing unaccompanied by an attempt to …
feedback for this behavior, exhibit excessive lever-pressing unaccompanied by an attempt to …
High but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive'lever-pressing in rats
The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the
entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the …
entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the …
Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex
A Dvorkin, C Silva, T McMurran… - European Journal of …, 2010 - Wiley Online Library
The quinpirole sensitization model of obsessive‐compulsive disorder was used to
investigate the functional role that brain regions implicated in a neuroanatomical circuit of …
investigate the functional role that brain regions implicated in a neuroanatomical circuit of …
Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action
The orbitofrontal cortex (OFC) and its major downstream target within the basal ganglia—the
rostromedial caudate nucleus (rmCD)—are involved in reward-value processing and goal …
rostromedial caudate nucleus (rmCD)—are involved in reward-value processing and goal …