Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
WS Samowitz, H Albertsen, J Herrick, TR Levin… - Gastroenterology, 2005 - Elsevier
Background & Aims: The concept of a CpG island methylator phenotype (CIMP), especially
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …
in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a …
CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer
YW Cheng, H Pincas, MD Bacolod, G Schemmann… - Clinical Cancer …, 2008 - AACR
Purpose: Aberrant promoter methylation and genomic instability occur frequently during
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown …
colorectal cancer development. CpG island methylator phenotype (CIMP) has been shown …
CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies
S Ogino, M Cantor, T Kawasaki, M Brahmandam… - Gut, 2006 - gut.bmj.com
Background: The concept of CpG island methylator phenotype (CIMP) is not universally
accepted. Even if specific clinicopathological features have been associated with CIMP …
accepted. Even if specific clinicopathological features have been associated with CIMP …
CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
N Hawkins, M Norrie, K Cheong, E Mokany, SL Ku… - Gastroenterology, 2002 - Elsevier
BACKGROUND &AIMS: Methylation of CpG islands is increasingly recognized as an
important event in colorectal carcinogenesis. We evaluated the extent of CpG island …
important event in colorectal carcinogenesis. We evaluated the extent of CpG island …
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
S Ogino, K Nosho, GJ Kirkner, T Kawasaki… - Gut, 2009 - gut.bmj.com
Background: The CpG island methylator phenotype (CIMP), characterised by widespread
promoter methylation, is associated with microsatellite instability (MSI) and BRAF mutation in …
promoter methylation, is associated with microsatellite instability (MSI) and BRAF mutation in …
The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status
AM Dahlin, R Palmqvist, ML Henriksson… - Clinical cancer …, 2010 - AACR
Purpose: The aim of this study was to relate the CpG island methylator phenotype (CIMP;
characterized by extensive promoter hypermethylation) to cancer-specific survival in …
characterized by extensive promoter hypermethylation) to cancer-specific survival in …
CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations
S Ogino, T Kawasaki, GJ Kirkner, M Loda… - The Journal of molecular …, 2006 - Elsevier
The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter
methylation seems to be a distinct epigenotype of colorectal cancer. However, no study has …
methylation seems to be a distinct epigenotype of colorectal cancer. However, no study has …
The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer
A Goel, T Nagasaka, CN Arnold, T Inoue, C Hamilton… - Gastroenterology, 2007 - Elsevier
Background & Aims: The CpG island methylator phenotype (CIMP) is one of the
mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the …
mechanisms involved in colorectal carcinogenesis (CRC). Although CIMP is probably the …
The CpG island methylator phenotype in colorectal cancer: progress and problems
LAE Hughes, CAJ Khalid-de Bakker, KM Smits… - … et Biophysica Acta (BBA …, 2012 - Elsevier
In recent years, attention has focused on the biology and potential clinical importance of the
CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). While it is generally …
CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). While it is generally …
Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample
K Nosho, N Irahara, K Shima, S Kure, GJ Kirkner… - PloS one, 2008 - journals.plos.org
Background The CpG island methylator phenotype (CIMP) is a distinct phenotype
associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent …
associated with microsatellite instability (MSI) and BRAF mutation in colon cancer. Recent …