To the psychologically minded, serotonin must seem the iconic neurotransmitter, emblematic
of brain and behavior in much the way DNA bespeaks genetic design. Popular imagination …

The ability to inhibit a response is an important component of normal behavioral control and
is an aspect of psychopathology when diminished. Converging evidence implicates the …

Abstract Tryptophan hydroxylase-2 (TPH2) is a newly identified second form of TPH
responsible for serotonin synthesis in the brain and has been increasingly implicated as a …

Tryptophan hydroxylase isoform 2 (TPH2) is a ratelimiting enzyme in the biosynthesis of
serotonin (5HT) and is predominantly localized in the brain. Previous studies have …

Findings relating serotonin to suicidal behavior suggest the role of genes for tryptophan
hydroxylase (TPH) in the genetic substrate of this disorder. Association of Tph1 gene and …

Psychiatric disorders, including affective disorders (AD) and schizophrenia (SZ) are among
the most common disabling brain diseases in Western populations and result in high costs …

The TPH1 and TPH2 genes encode the ratelimiting enzymes that control serotonin
biosynthesis, and serotonin is clearly altered in autism. In the current study, eight SNPs in …

Publisher Summary The chapter discusses the role of genes in the etiology of mood
disorders. The effects of genes may be direct and indirect such as modulation of the effects …

The tryptophan hydroxylase isoform-2 gene (TPH2) is located on chromosome 12 and is
expressed primarily in brain tissue. While genetic association and mRNA expression studies …

While the exact physiological mechanisms underlying cocaine dependence remain unclear,
a growing body of evidence indicates a role for the serotonergic neurotransmitter system in …