Platelet expression profiling and clinical validation of myeloid-related protein-14 as a novel determinant of cardiovascular events
AM Healy, MD Pickard, AD Pradhan, Y Wang, Z Chen… - Circulation, 2006 - Am Heart Assoc
Background—Platelets participate in events that immediately precede acute myocardial
infarction. Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs …
infarction. Because platelets lack nuclear DNA but retain megakaryocyte-derived mRNAs …
Therapeutic implications of the gender-specific aspects of cardiovascular disease
V Regitz-Zagrosek - Nature reviews Drug discovery, 2006 - nature.com
The manifestations of cardiovascular diseases differ between men and women, as do
outcomes after therapeutic interventions. It is important that those involved in drug discovery …
outcomes after therapeutic interventions. It is important that those involved in drug discovery …
Aspirin and clopidogrel resistance: an emerging clinical entity
Antiplatelet therapy is a cornerstone of cardiovascular medicine. Aspirin and clopidogrel
have emerged as critical therapies in the treatment of cardiovascular disease. Despite their …
have emerged as critical therapies in the treatment of cardiovascular disease. Despite their …
Sex differences in platelet reactivity and response to low-dose aspirin therapy
ContextRecent randomized trials suggest that women may not accrue the same
cardioprotective benefits as men do from low-dose aspirin therapy used in primary …
cardioprotective benefits as men do from low-dose aspirin therapy used in primary …
Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events
Background—Although randomized trials of cyclooxygenase-2 (COX-2) inhibitors have
shown increased cardiovascular risk, studies of nonselective, nonsteroidal antiinflammatory …
shown increased cardiovascular risk, studies of nonselective, nonsteroidal antiinflammatory …
Antiplatelet and anticoagulant therapy in patients with giant cell arteritis
Objective Vision loss and cerebrovascular accidents often complicate giant cell arteritis
(GCA). Antiplatelet and anticoagulant therapy reduce the risk of stroke in other populations …
(GCA). Antiplatelet and anticoagulant therapy reduce the risk of stroke in other populations …
Cardiovascular disease prevention with a multidrug regimen in the developing world: a cost-effectiveness analysis
TA Gaziano, LH Opie, MC Weinstein - The Lancet, 2006 - thelancet.com
Background Cardiovascular disease is the leading cause of death, with 80% of cases
occurring in developing countries. We therefore aimed to establish whether use of evidence …
occurring in developing countries. We therefore aimed to establish whether use of evidence …
[HTML][HTML] The exclusion of patients with chronic kidney disease from clinical trials in coronary artery disease
D Charytan, RE Kuntz - Kidney international, 2006 - Elsevier
Chronic kidney disease (CKD) is associated with a high risk of death from coronary artery
disease and may modify the response to standard cardiovascular therapies. Treatment of …
disease and may modify the response to standard cardiovascular therapies. Treatment of …
Healthy lifestyle and the risk of stroke in women
Background Healthy lifestyle has been associated with decreased risk of coronary heart
disease. In contrast, little is known about its association with stroke risk. Methods This is a …
disease. In contrast, little is known about its association with stroke risk. Methods This is a …
Reported outcomes in major cardiovascular clinical trials funded by for-profit and not-for-profit organizations: 2000-2005
PM Ridker, J Torres - Jama, 2006 - jamanetwork.com
ContextIn surveys based on data available prior to 2000, clinical trials funded by for-profit
organizations appeared more likely to report positive findings than those funded by not-for …
organizations appeared more likely to report positive findings than those funded by not-for …