Many neuropsychiatric disorders are considered to be related to the dysregulation of brain
serotonergic neurotransmission. Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific …

BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain
serotonin (5-HT) biosynthesis. Although dysfunction of 5-HT neurotransmission has been …

Impaired brain serotonin neurotransmission is a potential component of the diathesis of
major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic …

Serotonin [5-hydroxytryptamine (5-HT)] is a major therapeutic target of psychiatric disorders.
Tryptophan hydroxylase (TPH) catalyzes the rate-limiting reaction in the biosynthesis of 5 …

The brain serotonergic system has an essential role in the physiological functions of the
central nervous system and dysregulation of serotonin (5-HT) homeostasis has been …

Tryptophan hydroxylase 2 (TPH2) is the rate limiting enzyme of serotonin synthesis in the
brain. A recently described functional (C1473G) single nucleotide polymorphism in mouse …

Abstract Serotonin (5HT) is a neurotransmitter involved in many aspects of the neuronal
function. The synthesis of 5HT is initiated by the hydroxylation of tryptophan, catalyzed by …

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in the synthesis of brain
serotonin (5-HT). In a previous report, a single nucleotide polymorphism in mTph2 (C1473G) …

ABSTRACT Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme
of serotonin (5-HT) synthesis in the brain. Some polymorphic variants of the human Tph2 …

Recent studies have indicated that a newly identified second isoform of the tryptophan
hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal …