Objective: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme
in the biosynthesis of serotonin, has many biological functions and plays an important role …

Tryptophan hydroxylase (TPH), the rate limiting enzyme in serotonin biosynthesis, is one of
the most important regulating factors in the serotonergic system. Recently, polymorphisms of …

BACKGROUND: Tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of
serotonin, represents a major candidate in numerous genetic association analyses of …

BACKGROUND: Neurobiological studies implicate serotonergic dysfunction in suicidal
behavior. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of …

BACKGROUND: Serotonergic systems mediate a control of aggression and/or impulsivity in
human and are suggested to be involved in suicidal behavior. The newly identified neuronal …

Background Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase
(TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 …

According to WHO, suicide accounts for about 1 000 000 deaths worldwide every year. In
view of these dramatic data, several studies have tried to identify possible biological …

Background It is widely acknowledged that suicidal behavior (SB) has a genetic influence.
As a consequence, molecular genetic studies have been mostly conducted on serotonergic …

SEROTONERGIC dysfunction is implicated in mood disorders and suicidal behaviors.
Genetic variants of tryptophan hydroxylase (TPH), a rate-limiting enzyme in the biosynthesis …

Tryptophan hydroxylase isoform 2 (TPH2) is a ratelimiting enzyme in the biosynthesis of
serotonin (5HT) and is predominantly localized in the brain. Previous studies have …