Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

The past decade of efforts to find improved treatment for major depression has been
dominated by genome-driven programs of rational drug discovery directed toward highly …

Depression is a major cause of disability worldwide, but we know little about the underlying
fundamental biology. Research is hindered by the difficulties of modelling a disorder of …

Introduction Major depressive disorder is a complex and frequent psychiatric condition that
poses significant challenges to both the patients who experience it and the physicians who …

Depression, a complex psychiatric disorder that affects∼ 15% of the population, has an
enormous social cost. Although the disorder is thought to be the outcome of gene …

The need for newer compounds to treat depression is an ever-growing concern due to the
enormous societal and financial ramifications of this disorder. Here, we review some of the …

Major depressive disorder (MDD), also known as unipolar depression, is one of the leading
causes of disability and disease worldwide. The signs and symptoms are low self‑esteem …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Major depressive disorder (MDD) is considered a serious public health issue that adversely
impacts an individual's quality of life and contributes significantly to the global burden of …