Objectives: To assess the influence of the serotonin transporter variable number of tandem
repeat (HTT-VNTR) polymorphism and the serotonin transporter-gene-linked polymorphic …

Serotonergic pathways are known to play an essential role in the effects generated by
antidepressants. Polymorphisms in serotonin receptor and transporter genes have been …

Pharmacogenetics studies the genetic basis of an individual's ability to respond to
pharmacotherapy. Variability of this response is a major problem. Fatal adverse drug …

Major depression (MD) has a complex multifactorial etiology with genetic and environmental
factors contributing to the disorder. As with all antidepressant treatments, there is variability …

Objective This study investigates the relationship between the serotonin transporter linked
polymorphic region (5-HTTLPR) and the long-term outcome of antidepressant treatment …

The definition of a genetic liability profile for specific antidepressant treatment will soon be
available offering considerable help in early detection of effective therapy in affective …

Modulations of serotonergic and noradrenergic systems are thought to be critical to the
therapeutic effect of most antidepressants, and their efficacies have been shown to depend …

Sažetak Depression pharmacotherapy can be described with weak predictability of
individual response. Antidepressants are prescribed based on trial and error, as it is not …

In the last decade the serotonin transporter gene promoter polymorphism (5-HTTLPR) was
likely the most studied genetic variant as predictor of antidepressant response. Nevertheless …

The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly
associated with antidepressant response in mood disorder patients, but findings are not …