The CCR6 chemokine receptor is expressed by most B cells and subsets of T cells and
dendritic cells (DCs) found in the gut mucosal immune system. CCL20, the single …

The chemokine receptor CCR6 is expressed by dendritic cells, B and T cells predominantly
within the organized structures of the gut-associated lymphatic tissue. Its ligand CCL20 is …

Isolated lymphoid follicles (ILFs) are organized lymphoid structures that facilitate the efficient
interaction of antigen, antigen-presenting cells, and lymphocytes to generate controlled …

Earlier studies have demonstrated an important role for the chemokine CCL25, and its
receptor CCR9, in the generation of the small intestinal lymphocyte compartment. The work …

The recruitment of antigen-specific T lymphocytes to the intestinal mucosa is central to the
development of an effective mucosal immune response, yet the mechanism by which this …

CCL25 and CCR9 constitute a chemokine/receptor pair involved in T cell development and
in gut-associated immune responses. In this study, we generated CCL25−/− mice to answer …

The CC chemokine receptors CCR6, CCR9, and CCR10 all contribute to the positioning of
leukocytes at mucosal locations. Mucosal epithelial cells are major sources of the …

Humoral immunity in the gut-associated lymphoid tissue is characterized by the production
of immunoglobulin A (IgA) by antibody-secreting plasma cells (PCs) in the lamina propria …

Small intestinal cryptopatches (CP) are the major anatomic site for extrathymic differentiation
by precursors destined to become intestinal intraepithelial T lymphocytes (IEL). We found …

Chemokines constitute a large family of low-molecular-weight proteins (∼ 10 kDa in size),
recognized primarily for their role in directing leukocyte migration under both homeostatic …