The aim of the present experiment was to investigate the effects of cocaine primes and
exposure to foot shock stress on reinstatement of operant responding maintained by a …

Rationale The exact behavioral nature of drug-induced reinstatement of drug seeking is still
debated. As an incentive, the drug can have general facilitatory influences on appetitive …

A conditioned-suppression procedure was used to study drug conditioning using cocaine as
the unconditioned stimulus (UCS). Rats were first trained to nose poke for food …

Sensitization has been hypothesized to increase the incentive salience of drug-paired
conditioned stimuli and in the present study the ability of a sensitizing pretreatment with …

Cocaine conditioned stimuli are capable of eliciting cocaine craving in individuals with a
history of cocaine use. As a consequence, there have been a number of attempts using …

Shock-paired stimuli have produced conditioned suppression of behavior maintained by a
variety of reinforcers such as food, water, sucrose, and intracranial self-stimulation. With the …

With repeated cocaine use, cocaine conditioned behavior develops to associated stimuli,
and in addition, sensitization can occur to the unconditioned stimulant effects of cocaine. To …

According to a recent account of addiction, dopaminergic effects of drugs like cocaine mimic
the neuronal signal that occurs when a natural reward has a larger value than expected …

Although extinction has been used as a treatment to reduce the power of drug cues, a better
method is needed. Research with traditional reinforcers has shown that counterconditioning …

Rationale Cocaine addiction is a relapsing psychiatric disorder with a high prevalence in
developed countries. To date, the reinstatement model has been difficult to implement in …