The immature brain may be particularly vulnerable to injury during critical periods of
development. To address the biologic basis for this vulnerability, mice were subjected to …

Although diffuse axonal injury is the primary pathology in pediatric brain trauma, the
additional presence of focal contusions may contribute to the poor prognosis in brain-injured …

We characterized the regional and temporal patterns of neuronal injury and axonal
degeneration after controlled cortical impact of moderate severity in mice at postnatal day …

Diffuse axonal injury is a significant component of the pathology of moderate-severe
pediatric traumatic brain injury in children less than 4 years of age, and is associated with …

Infants and children less than 4 years old suffer chronic cognitive deficits following mild,
moderate or severe diffuse traumatic brain injury (TBI). It has been suggested that the …

Traumatic brain injury (TBI) affects many infants and children, and results in enduring motor
and cognitive impairments with accompanying changes in white matter tracts, yet few …

The purpose of experimental models of traumatic brain injury (TBI) is to reproduce selected
aspects of human head injury such as brain edema, contusion or concussion, and functional …

The immature brain in the first several years of childhood is very vulnerable to trauma.
Traumatic brain injury (TBI) during this critical period often leads to neuropathological and …

Trauma to the developing brain constitutes a poorly explored field. Some recent studies
attempting to model and study pediatric head trauma, the leading cause of death and …

There is a general view that early brain damage leads to a far better outcome than damage
later in life. Although there is a grain of truth to this idea, the reality is far more complex. We …