Morphine withdrawal produces a hypofunction of mesencephalic dopamine (DA) neurons
which impinge upon medium spiny neurons (MSN) of the forebrain. After chronic treatment …

Morphine withdrawal produces a hypofunction of mesencephalic dopamine neurons that
impinge upon medium spiny neurons (MSN) of the forebrain. After chronic treatment (from …

We studied the effects of self‐administered (SA) vs. experimenter‐administered (EA)
morphine on dendritic spines in the hippocampal formation (CA1 and dentate), nucleus …

Repeated intermittent treatment with amphetamine increases the density of dendritic spines
on medium spiny neurons (MSNs) in the nucleus accumbens (NAcc). The purpose of this …

Chronic cocaine exposure influences the density and morphology of dendritic spines on
medium spiny neurons (MSNs) in the nucleus accumbens (NAc), a critical brain region for …

Rats were given repeated injections of 10 mg/kg of morphine and were then left undisturbed
for 24–25 days before their brains were processed for Golgi‐Cox staining. Prior exposure to …

Nucleus accumbens receives a dense dopaminergic innervation which is important in
regulating motivated states of behavior such as goal-directed actions, stimulus-reward …

Exposure to drugs of abuse can result in profound structural modifications on neurons in
circuits involved in addiction that may contribute to drug dependence, withdrawal and …

Highlights•Accumbal dendritic spine changes are observed within 1–3 days of the 1st
cocaine use.•Three-11d of cocaine leads to short-lived spine increases that are lost after 1 …

Opioids are effective analgesic agents but serious adverse effects such as tolerance and
withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal involves …