During the past 5 years, gene expression studies in cell culture, animal models and in the
brains of patients have shown that the perturbation of transcription frequently results in …

Transcriptional dysregulation plays a major role in the pathology of Huntington's disease
(HD). However, the mechanisms causing selective downregulation of genes remain …

Perturbation of histone acetyl‐transferase (HAT) activity is implicated in the pathology of
polyglutamine diseases, and suppression of the counteracting histone deacetylase (HDAC) …

Transcriptional dysregulation is an important early feature of polyglutamine diseases. One of
its proposed causes is defective neuronal histone acetylation, but important aspects of this …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine repeat expansion within the huntingtin protein. HD is characterized by …

Polyglutamine diseases include at least nine neurodegenerative disorders, each caused by
a CAG repeat expansion in a different gene. Accumulation of mutant polyglutamine …

Huntington's disease is an autosomal dominantly inherited neurodegenerative disorder
caused by a polyglutamine repeat expansion. The onset of HD leads to problems with …

Huntington's disease (HD) is an inherited, progressive neurological disorder that is caused
by a CAG/polyglutamine repeat expansion and for which there is no effective therapy …

Proteins with expanded polyglutamine repeats cause Huntington's disease and other
neurodegenerative diseases. Transcriptional dysregulation and loss of function of …

Huntington's disease (HD) is the most common monogenic neurodegenerative disease and
the commonest genetic dementia in the developed world. With autosomal dominant …