Abstract Spinocerebellar Ataxia type 1 (SCA1) and Huntington's disease (HD) are two
polyglutamine disorders caused by expansion of a CAG repeat within the coding regions of …

Polyglutamine (polyQ) diseases are inherited neurodegenerative disorders caused by the
expansion of the CAG trinucleotide repeats coding for polyglutamine (polyQ) in the gene …

The fruit fly, Drosophila melanogaster, has been used extensively as an experimental model
organism since the beginning of the last century. More recently, the concept of large-scale …

Studies of inherited neurological diseases in genetically tractable model organisms allow
rapid identification of cellular pathways that go awry in pathogenic conditions. Several …

Polyglutamine (polyQ) diseases, resulting from a dynamic expansion of glutamine repeats in
a polypeptide, are a class of genetically inherited late onset neurodegenerative disorders …

Although polyglutamine expansion diseases are the most common genetically inherited
neurodegenerative disorders, the key pathogenic mechanisms that lead to neuronal cell …

Polyglutamine (polyQ) diseases, resulting from a dynamic expansion of glutamine repeats in
a polypeptide, are a class of genetically inherited, late-onset neurodegenerative disorders …

The polyglutamine diseases are the most common form of inherited neurodegenerative
disorders. Each of the polyglutamine diseases stems from the same underlying cause: a …

Human neurodegenerative diseases, including the polyglutamine diseases like Huntington's
disease and Spinocerebellar ataxia type 3, are late-onset progressive neurodegenerative …

The expansion of polyglutamine tracts in a variety of proteins causes devastating,
dominantly inherited neurodegenerative diseases, including six forms of spinal cerebellar …