In mammals, the circadian hormone melatonin targets two seven‐transmembrane–spanning
receptors, MT1 and MT2, of the G protein‐coupled receptor (GPCR) super‐family. Evidence …

The human melatonin MT1 receptor—belonging to the large family of G protein-coupled
receptors (GPCRs)—plays a key role in circadian rhythm regulation and is notably involved …

One‐third of the∼ 400 nonodorant G protein‐coupled receptors (GPCRs) are still orphans.
Although a considerable number of these receptors are likely to transduce cellular signals in …

Heterodimerization has been documented for several members of the G protein-coupled
receptor (GPCR) superfamily, including the closely related MT1 and MT2 melatonin …

Melatonin receptors play important roles in the regulation of circadian and seasonal
rhythms, sleep, retinal functions, the immune system, depression, and type 2 diabetes …

The formation of G protein (heterotrimeric guanine nucleotide–binding protein)–coupled
receptor (GPCR) heteromers enables signaling diversification and holds great promise for …

The melatonin receptor subfamily is composed of three members, MT 1 and MT 2, which are
binding to melatonin, and GPR50, which shows high sequence homology to MT 1 and MT 2 …

Melatonin is a neurohormone that has been claimed to be involved in a wide range of
physiological functions. Nevertheless, for most of its effects, the mechanism of action is not …

Melatonin receptors have been described to activate different G protein–dependent
signaling pathways, both in laboratory, heterologous, cellular models and in physiological …

Background and Purpose Melatonin receptors have been extensively characterized
regarding their affinity and pharmacology, mostly using 2‐[125I]‐melatonin as a radioligand …