Background and rationale The reinstatement model is widely used to study relapse to drug
addiction. However, the model's validity is open to question. Objective We assess the …

Objectives This commentary assesses the degree to which the reinstatement model is
homologous to the human experience of relapse. Results A review of the literature suggests …

Rationale The reinstatement procedure has been used increasingly as a laboratory model of
craving and relapse to drug abuse. With the number of reports involving this procedure …

Rational and objectives. The reinstatement model is currently used in many laboratories to
investigate mechanisms underlying relapse to drug seeking. Here, we review briefly the …

While substance use disorders have long been recognized as chronic relapsing conditions,
it has mainly been in the last two decades that clinical researchers have been systematically …

The author provides a commentary on a series of articles published on relapse to substance
abuse. The following points summarize this commentary: animal and human studies of drug …

High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

Binary thinking has often guided research and practice in the addiction field. For example,
emphasis has been given to identifying whether an individual is" alcoholic" or not, and the …

Drug craving and relapse to drug use during abstinence are defining features of addiction.
Evidence indicates that drug craving and relapse in humans are often provoked by acute …

Relapse to drug use during abstinence is a defining feature of addiction. During the last
several decades, this clinical scenario has been studied at the preclinical level using classic …