Background Previous studies have demonstrated reexpression of cell-cycle markers within
postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD) …

Target of rapamycin (TOR) signaling is a regulator of cell growth. TOR activity can also
enhance cell death, and the TOR inhibitor rapamycin protects cells against proapoptotic …

Accumulation of tau is a critical event in several neurodegenerative disorders, collectively
known as tauopathies, which include Alzheimer's disease and frontotemporal dementia …

Postmitotic neurons require persistently active controls to maintain terminal differentiation.
Unlike dividing cells, aberrant cell cycle activation in mature neurons causes apoptosis …

Previous evidence from post-mortem Alzheimer disease (AD) brains and drug (especially
rapamycin)-oriented in vitro and in vivo models implicated an aberrant accumulation of the …

Mutations in the microtubule-associated protein tau gene have been linked to neurofibrillary
tangle (NFT) formation in several neurodegenerative diseases known as tauopathies; …

In Alzheimer's disease and related disorders, the microtubule-associated protein Tau is
abnormally hyperphosphorylated and aggregated into neurofibrillary tangles. Mutations in …

In Alzheimer's disease tauopathy is considered secondary to amyloid, and the duality
obscures their relation and the definition of their respective contributions. Transgenic mouse …

Cell growth (increase in cell mass or size) is tightly coupled to nutrient availability, growth
factors and the energy status of the cell. The target of rapamycin (TOR) integrates all three …

Multisite hyperphosphorylation of tau has been implicated in the pathogenesis of
neurodegenerative diseases including Alzheimer's disease (AD). However, the …