Activity of the epithelial Na+ channel (ENaC) is limiting for Na+ absorption across many
epithelia. Consequently, ENaC is a central effector impacting systemic blood volume and …

Small G proteins in the Rho family are known to regulate diverse cellular processes,
including cytoskeletal organization and cell cycling, and more recently, ion channel activity …

The epithelial Na+ channel (ENaC) plays a central role in control of epithelial surface
hydration and vascular volume. Similar to other ion channels, ENaC activity is set, in part, by …

Aldosterone induces expression and activation of the GTP-dependent signaling switch K-
Ras. This small monomeric G protein is both necessary and sufficient for activation of the …

Hormonal control of transepithelial sodium (Na+) transport utilizes phosphatidylinositide 3′-
kinase (PI3K) and Raf–MAPK/ERK kinase (MEK)–ERK-dependent signaling pathways …

Abstract The Epithelial Na+ Channel, ENaC, comprised of 3 subunits (αβγ, or sometimes
δβγENaC), plays a critical role in regulating salt and fluid homeostasis in the body. It …

Na+ transport across epithelia is mediated in part by the epithelial Na+ channel ENaC.
Previous work indicates that Na+ is an important regulator of ENaC, providing a negative …

Membrane phospholipids, such as phosphatidylinositol 3, 4, 5-trisphosphate (PI (3, 4, 5) P
3), are signaling molecules that can directly modulate the activity of ion channels, including …

Several distinct types of ion channels bind and directly respond to phosphatidylinositides,
including phosphatidylinositol (3, 4, 5)‐trisphosphate (PI (3, 4, 5) P3) and …

Activity of the epithelial Na+ channel (ENaC) is rate-limiting for Na+(re) absorption across
electrically tight epithelia. ENaC is a heteromeric channel comprised of three subunits, α, β …