To examine the effects of increased expression of Cx50 in the mouse lens, transgenic mice
were generated using a DNA construct containing the human Cx50 coding region and a C …

Human connexin46 (hCx46) forms gap junctional channels interconnecting lens fiber cells
and appears to be critical for normal lens function, because hCx46 mutations have been …

PURPOSE: To investigate the role of the gap junction protein connexin43 (Cx43), which is
predominantly expressed in lens epithelial cells in the control of lens development and …

In the ocular lens, gap junctional communication is a key component of homeostatic
mechanisms preventing cataract formation. Gap junctions in rodent lens fibers contain two …

Mutations within connexin50 (Cx50) have been linked to various cataract phenotypes. To
determine the mechanism behind cataract formation we used the paired Xenopus oocyte …

Purpose.: Although many connexin46 (Cx46) mutants have been linked to inherited human
cataracts, there are no adequate animal models for their study. The current experiments …

Purpose.: Substitutions of aspartate-47 (D47) of Connexin50 (Cx50) have been linked to
autosomal dominant congenital cataracts in several human pedigrees. To elucidate the lens …

PURPOSE: To identify, clone molecularly, characterize immunochemically, and express
functionally a bovine lens gap junction protein (connexin). METHODS: The methods used …

A mutant human connexin50 (hCx50), hCx50P88S, has been linked to cataracts inherited as
an autosomal dominant trait. The functional, biochemical and cellular behavior of wild-type …

Mutations in connexin50 (Cx50) cause dominant cataracts in both humans and mice. The
exact mechanisms by which mutations cause these variable phenotypes are poorly …