Cisplatin is among the most important chemotherapeutic agents ever developed. It is a
critical component of therapeutic regimens in a broad range of malignancies. However …

Purpose: Cisplatin adducts to nuclear DNA (nDNA) are felt to be the molecular lesions that
trigger apoptosis, but the mechanism linking nDNA adduct formation and cell death is …

Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent
recurrence of resistance phenomena, it still remains the only therapeutic option for several …

We studied the relationship between the mitochondrial density in the cells and the cellular
sensitivity to the toxicity of cis-diaminedichloroplatinum II (cisplatin), a potent anticancer …

Resistance to apoptosis is a frequent characteristic of cancer cells and participates both in
the initial phase of carcinogenesis and in the development of chemotherapy resistance …

The evolving role of mitochondria as a target for many anticancer drugs (eg platinum-based
compounds, alkylating agents and anthracyclines) prompted us to investigate their …

Tumor resistance to chemotherapy is the major obstacle to employ cisplatin, one of the
broadly used chemotherapeutic drugs, for effective treatment of various tumors in the clinic …

Chemoresistant cells have acquired the ability to evade the action of multiple classes of anti-
neoplastic compounds. One mechanism by which tumor cells survive in the presence of …

Mitochondria, the power houses of the cell, are at the cross-road of many cellular pathways.
They play a central role in energy metabolism, regulate calcium flux and are implicated in …

One of the mechanisms of cisplatin cell cytotoxicity is the mitochondria-associated induction
of apoptosis. The morphological or functional change of mitochondria in cisplatin-resistant …