Cell death programs are major players in tissue homeostasis, development and cellular
stress responses. A prominent cause of malignant transformation is the cumulative genetic …

The regulation of apoptotic cell death, a terminal and fatal cell fate decision, has been
intensely investigated and, due to its paramount implications for human health and disease …

Cell death has historically been subdivided into regulated and unregulated mechanisms.
Apoptosis, a form of regulated cell death, reflects a cell's decision to die in response to cues …

Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Apoptosis, or programmed cell death, is a gene‐directed mechanism activated as a suicidal
event to get rid of excess, damaged, or infected cells. The recent astounding pace of …

Apoptosis—programed cell death—is the most common form of death in the body. Once
apoptosis is induced, proper execution of the cell death program requires the coordinated …

Cell death is a fundamental physiological process in all living organisms. Processes such as
embryonic development, organ formation, tissue growth, organismal immunity, and drug …

Research performed over the past decade has transformed apoptosis from a distinctive form
of cell death known only by its characteristic morphology and genomic destruction to an …

Apoptosis is a complex but highly defined cellular program of cell demolition. Apoptosis can
be triggered by the extrinsic or the intrinsic death pathways. Deregulation of apoptosis leads …

Apoptosis, or programmed cell death, is the physiological process whereby individual cells
are deliberately eliminated to achieve homeostasis and proper metazoan development …