Adenosine is one of the principal neuromodulators in the brain and acts on four specific
receptor subtypes: the A1, A2A, A2B and A3 receptors. Adenosine concentrations normally …

After a review of the metabolism and pharmacology of adenosine, this work will examine the
various therapeutic possibilities involving the use of agonists or antagonists of adenosine A1 …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

Adenosine is released from active neurons into the extracellular fluid at a concentration of
about 1 μ mol/l. Neither the precise cellular origin nor the biochemical form of release has …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

Adenosine is a naturally occurring nucleoside present ubiquitously throughout the body as a
metabolic intermediate. Besides its metabolic role within the cells, adenosine is released …

▪ Abstract Adenosine is a modulator that has a pervasive and generally inhibitory effect on
neuronal activity. Tonic activation of adenosine receptors by adenosine that is normally …

Adenosine A2B and, much more importantly, adenosine A2A receptors modulate many
physiological and pathological processes in the brain. In this review, the most recent …

Adenosine is a ubiquitous homeostatic substance released from most cells, including
neurones and glia. Once in the extracellular space, adenosine modifies cell functioning by …

Adenosine is involved as an endogenous modulator of nerve and glial cell functions in
pathological processes occurring in conditions of hypoxia/hypoglycemia and also in …