Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac
allograft vasculopathy and death in heart transplant recipients. Endothelial overproduction of …

Both in vivo models of ischemia/reperfusion and in vitro models of hypoxia
(H)/reoxygenation (R) have demonstrated the crucial role of the Rac1-regulated NADPH …

The intracellular signaling events by which NADPH oxidase-generated reactive oxygen
species (ROS) modulate vascular smooth muscle cell (VSMC) function and atherogenesis …

Background Endothelial dysfunction contributes significantly to the development of vascular
diseases. However, a therapy able to reduce this derangement still needs to be identified …

Reactive oxygen species (ROS) including superoxide (O2.−) and hydrogen peroxide (H2O2)
are produced endogenously in response to cytokines, growth factors; G-protein coupled …

Experimental animals placed on a high-cholesterol diet for 2 or more weeks exhibit an
inflammatory response in postcapillary venules. The aims of this study were to determine (1) …

BACKGROUND: Many non-immunologic factors contribute to the development of cardiac
allograft vasculopathy (CAV), chief among them being ischemia-reperfusion injury …

Objective: Anoxia followed by reoxygenation (A/R) increases endothelial cell superoxide
(O2−) generation which is implicated in E-selectin overexpression. The mechanisms which …

Cultured human endothelial cells (EC) exposed to atherogenic low-density lipoprotein levels
have increased reactive oxygen species (ROS) generation. The enzyme responsible for this …

Exposure to atherogenic levels of low-density lipoprotein (LDL) causes elevated reactive
oxygen species (ROS) production by human endothelial cells (ECs). NADPH oxidase is …