Despite years of research work, biologists remain divided over the issue of zona pellucida
function during fertilization and the mode of sperm-ZP penetration. The present review …

The ubiquitin-proteasome pathway has been implicated in the penetration of ascidian
vitelline envelope by the fertilizing spermatozoon (Sawada et al., Proc Natl Acad Sci USA …

Despite decades of research, the mechanism by which the fertilizing spermatozoon
penetrates the mammalian vitelline membrane, the zona pellucida (ZP) remains one of the …

The 26S proteasome is a multi-subunit protease specifically targeting ubiquitinated proteins.
A consensus has emerged from studies by multiple laboratories on the role of sperm-borne …

The 26S proteasome, which is a multi-subunit protease with specificity for substrate proteins
that are postranslationally modified by ubiquitination, has been implicated in acrosomal …

The omnipresent ubiquitin–proteasome system (UPS) is an ATP-dependent enzymatic
machinery that targets substrate proteins for degradation by the 26S proteasome by tagging …

Proteolysis of ubiquitinated sperm and oocyte proteins by the 26S proteasome is necessary
for the success of mammalian fertilization, including but not limited to acrosomal exocytosis …

Extracellular ATP has been implicated in a number of cellular events, including mammalian
sperm function. The complement of ATP-dependent sperm proteins includes six subunits of …

Sperm-associated proteasomes have been suggested to play an important role during
fertilization in animals. To delineate the role of these proteasomes during fertilization in …

The 26S proteoasome is a multi-subunit protease specific to ubiquitinated substrate
proteins. It is composed of a 20S proteasomal core with substrate degradation activity, and a …