There is considerable evidence of interactions between adenosine A2A receptors and
dopamine D2 receptors in striatal areas, and antagonists of the A2A receptor have been …

Forebrain dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation. Adenosine A2A antagonists reverse many of the behavioral effects of DA …

In the striatum, dopamine D2 receptors are co-localized with adenosine A2A receptors on
the GABAergic neurons of the striopallidal pathway. Moreover, blockade of A2A receptors …

Recent evidence indicates that adenosine A2A receptors modulate the activity of striatal
neurons, and that antagonists of this receptor may have actions in various animal models …

The nucleus accumbens (NAc) subserves behaviors governed by natural rewards, ie,
feeding or exploration, and has been implicated in control of prepulse inhibition (PPI), a …

Adenosine A2A antagonists can exert antiparkinsonian effects in animal models. Recent
experiments studied the ability of MSX-3 (an adenosine A2A antagonist) to reverse the …

The effects on locomotor activity (LA) of selective agonists for adenosine receptor subtypes
were examined in mice following bilateral injections into the nucleus accumbens (ACB). The …

Several evidences indicate that the selective blockade of adenosine A2A receptors
counteracts the motor activity impairment in experimental models of Parkinson's disease. In …

Adult male mice were stereotaxically implanted with permanent indwelling guide cannulae
for bilateral injections into the nucleus accumbens (ACB). The effects on spontaneous …

Dopamine D2 and adenosine A2A receptors interact to regulate aspects of motor and
motivational function, and it has been suggested that adenosine A2A antagonists could be …