RIG-I is an RNA helicase containing caspase activation and recruitment domains (CARDs).
RNA binding and signaling by RIG-I are implicated in pathogen recognition and triggering of …

Virus-responsive signaling pathways that induce alpha/beta interferon production and
engage intracellular immune defenses influence the outcome of many viral infections. The …

Recognition of viral RNA structures by the intracytosolic RNA helicase RIG-I triggers
induction of innate immunity. Efficient induction requires RIG-I ubiquitination by the E3 ligase …

ABSTRACT RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that
triggers the alpha/beta interferon (IFN-α/β) immune defenses. However, the mechanism for …

The innate immune system is essential for controlling viral infections, but several viruses
have evolved strategies to escape innate immunity. RIG-I is a cytoplasmic viral RNA sensor …

Upon recognition of specific molecular patterns on microbes, host cells trigger an innate
immune response, which culminates in the production of type I interferons, proinflammatory …

During virus infection, multiple immune signaling pathways are triggered, both within the
host cell and bystander cells of an infected tissue. These pathways act in concert to mediate …

Innate immune defences are essential for the control of virus infection and are triggered
through host recognition of viral macromolecular motifs known as pathogen-associated …

RIG-I is an essential innate immune receptor for detecting and responding to infection by
RNA viruses. RIG-I specifically recognizes the unique molecular features of viral RNA …

RNA helicase-like receptors MDA-5 but not RIG-I has been shown to be essential for
triggering innate immune responses against picornaviruses. However, virus–host co …