This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …

Over the past 5 years, the adenosine A2A receptor (A2AR) is emerging as an attractive
therapeutic target for modulating brain injury in a variety of animal models of neurological …

This review summarizes recent developments that have contributed to our understanding of
how adenosine 2A receptors (A2ARs) modulate brain damage in various animal models of …

The inhibitory adenosine A1 receptor (A1R) and excitatory A2A receptor (A2AR) are
predominantly expressed in the brain. Whereas the A2AR has been implicated in normal …

Adenosine acts as a neurotransmitter in the brain through the activation of four specific G‐
protein‐coupled receptors (the A1, A2A, A2B, and A3 receptors). The A1 receptor has long …

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …

A. Cellular and Subcellular Localization B. Pharmacological Tools to Study Adenosine
Receptors C. Signaling Via Adenosine Receptors D. Regulation of Receptor Expression and …

The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Extracellular adenosine critically modulates ischemic brain injury, at least in part through
activation of the A1 adenosine receptor. However, the role played by the A2A receptor has …