Background Chronic hypoxia induces pulmonary arterial hypertension (PAH). Smooth
muscle cell (SMC) proliferation and hypertrophy are important contributors to the remodeling …

Pulmonary hypertension (PH) is a common complication of chronic hypoxic lung diseases,
which increase morbidity and mortality. Hypoxic PH has previously been attributed to …

RhoA GTPase mediates a variety of cellular responses, including activation of the contractile
apparatus, growth, and gene expression. Acute hypoxia activates RhoA and, in turn, its …

Pulmonary arterial vascular smooth muscle (PAVSM) cell proliferation is a key
pathophysiological component of vascular remodeling in pulmonary arterial hypertension …

Thiazolidinediones (TZDs) are insulin-sensitizing agents that also decrease systemic blood
pressure, attenuate the formation of atherosclerotic lesions, and block remodeling of injured …

Chronic hypoxia-induced pulmonary hypertension results partly from proliferation of smooth
muscle cells in small peripheral pulmonary arteries. Therefore, we examined the effect of …

Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension
(PH) may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The …

Chronic pulmonary hypertension in infancy and childhood is characterized by a fixed and
progressive increase in pulmonary arterial pressure and resistance, pulmonary arterial …

Pulmonary hypertension occurs commonly in patients with chronic hypoxic lung disease and
is characterized by the remodeling of the pulmonary artery walls. The molecular …

Many cardiopulmonary diseases are associated with pulmonary hypertension which adds
significant co-morbidity. Pulmonary hypertension is due partly to vasoconstriction but …