The functional impact of SLC6 transporter genetic variation

MK Hahn, RD Blakely - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
Abstract Solute carrier 6 (SLC6) is a gene family of ion-coupled plasma membrane
cotransporters, including transporters of neurotransmitters, amino acids, and osmolytes that …

Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation

HE Melikian - Pharmacology & therapeutics, 2004 - Elsevier
Sodium-and chloride-dependent transporters in the SLC6 gene family are key regulators of
extracellular neurotransmitter levels and are required for normal neurotransmission …

[HTML][HTML] Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes

F Herborg, TF Andreassen, F Berlin, CJ Loland… - Journal of Biological …, 2018 - ASBMB
Genetic factors are known to significantly contribute to the etiology of psychiatric diseases
such as attention deficit hyperactivity disorder (ADHD) and autism spectrum and bipolar …

Human genetics and pharmacology of neurotransmitter transporters

Z Lin, BK Madras - Neurotransmitter transporters, 2006 - Springer
Biogenic amine neurotransmitters are released from nerve terminals and activate pre-
andpostsynaptic receptors. Released neurotransmitters are sequesteredby transporters into …

SLC6 neurotransmitter transporters: structure, function, and regulation

AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …

Expression and function of organic cation and anion transporters (SLC22 family) in the CNS

CA Farthing, DH Sweet - Current pharmaceutical design, 2014 - ingentaconnect.com
A major function of the blood brain barrier (BBB) and blood cerebrospinal fluid barrier
(BCSFB) is to exert selective control over the flux of organic cations and anions into and out …

Synaptic uptake and beyond: the sodium-and chloride-dependent neurotransmitter transporter family SLC6

NH Chen, MEA Reith, MW Quick - Pflügers Archiv, 2004 - Springer
The SLC6 family is a diverse set of transporters that mediate solute translocation across cell
plasma membranes by coupling solute transport to the cotransport of sodium and chloride …

[HTML][HTML] The dopamine transporter gene SLC6A3: multidisease risks

MEA Reith, S Kortagere, CE Wiers, H Sun… - Molecular …, 2022 - nature.com
The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …

The solute carrier 6 family of transporters

S Bröer, U Gether - British journal of pharmacology, 2012 - Wiley Online Library
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …

A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder

CH Kim, MK Hahn, Y Joung… - Proceedings of the …, 2006 - National Acad Sciences
The norepinephrine transporter critically regulates both neurotransmission and homeostasis
of norepinephrine in the nervous system. In this study, we report a previously …