The functional impact of SLC6 transporter genetic variation
MK Hahn, RD Blakely - Annu. Rev. Pharmacol. Toxicol., 2007 - annualreviews.org
Abstract Solute carrier 6 (SLC6) is a gene family of ion-coupled plasma membrane
cotransporters, including transporters of neurotransmitters, amino acids, and osmolytes that …
cotransporters, including transporters of neurotransmitters, amino acids, and osmolytes that …
Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation
HE Melikian - Pharmacology & therapeutics, 2004 - Elsevier
Sodium-and chloride-dependent transporters in the SLC6 gene family are key regulators of
extracellular neurotransmitter levels and are required for normal neurotransmission …
extracellular neurotransmitter levels and are required for normal neurotransmission …
[HTML][HTML] Neuropsychiatric disease–associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes
Genetic factors are known to significantly contribute to the etiology of psychiatric diseases
such as attention deficit hyperactivity disorder (ADHD) and autism spectrum and bipolar …
such as attention deficit hyperactivity disorder (ADHD) and autism spectrum and bipolar …
Human genetics and pharmacology of neurotransmitter transporters
Biogenic amine neurotransmitters are released from nerve terminals and activate pre-
andpostsynaptic receptors. Released neurotransmitters are sequesteredby transporters into …
andpostsynaptic receptors. Released neurotransmitters are sequesteredby transporters into …
SLC6 neurotransmitter transporters: structure, function, and regulation
AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
Expression and function of organic cation and anion transporters (SLC22 family) in the CNS
CA Farthing, DH Sweet - Current pharmaceutical design, 2014 - ingentaconnect.com
A major function of the blood brain barrier (BBB) and blood cerebrospinal fluid barrier
(BCSFB) is to exert selective control over the flux of organic cations and anions into and out …
(BCSFB) is to exert selective control over the flux of organic cations and anions into and out …
Synaptic uptake and beyond: the sodium-and chloride-dependent neurotransmitter transporter family SLC6
NH Chen, MEA Reith, MW Quick - Pflügers Archiv, 2004 - Springer
The SLC6 family is a diverse set of transporters that mediate solute translocation across cell
plasma membranes by coupling solute transport to the cotransport of sodium and chloride …
plasma membranes by coupling solute transport to the cotransport of sodium and chloride …
[HTML][HTML] The dopamine transporter gene SLC6A3: multidisease risks
MEA Reith, S Kortagere, CE Wiers, H Sun… - Molecular …, 2022 - nature.com
The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …
The solute carrier 6 family of transporters
The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …
A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder
CH Kim, MK Hahn, Y Joung… - Proceedings of the …, 2006 - National Acad Sciences
The norepinephrine transporter critically regulates both neurotransmission and homeostasis
of norepinephrine in the nervous system. In this study, we report a previously …
of norepinephrine in the nervous system. In this study, we report a previously …