The major isoform of nitric oxide synthase (NOS) in skeletal muscle is the splice variant of
neuronal NOS, termed nNOSμ. Exercise training increases nNOSμ protein levels in rat …

The effect of endurance training on neuronal nitric oxide synthase (nNOS) content and
distribution in muscle was investigated. Seven male subjects performed 6 wk of one-legged …

Skeletal muscle inducible nitric oxide synthase (NOS) protein is greatly elevated in people
with type 2 diabetes mellitus, whereas endothelial NOS is at normal levels. Diabetic rat …

Neuronal nitric oxide synthases (nNOS) are Ca 2+/calmodulin-activated enzymes that
synthesize the gaseous messenger nitric oxide (NO). nNOSμ and the recently described …

Type 2 Diabetes (T2DM) is the seventh leading cause of death in the United States, and is
quickly becoming a global pandemic. T2DM results from reduced insulin sensitivity coupled …

Skeletal muscle constitutively expresses both the type I (neuronal) and type III (endothelial)
isoforms of nitric oxide synthase (NOS). We tested the functional importance of type III NOS …

This study examined the effects of acute exercise on skeletal muscle nitric oxide synthase
(NOS) activity. Female Sprague-Dawley rats were divided into three groups: control …

Signaling via the neuronal NOS (nNOS) splice variant nNOSμ is essential for skeletal
muscle health and is commonly reduced in neuromuscular disease. nNOSμ is thought to be …

Nitric oxide (NO·) is a multifunctional messenger molecule generated by a family of enzymes
called the nitric oxide synthases (NOSs). Although NOSs have been identified in skeletal …

In the past five years, skeletal muscle has emerged as a paradigm of “nitric oxide”(NO)
function and redox-related signaling in biology. All major nitric oxide synthase (NOS) …