The aim of this review is to summarize and critically discuss the complex role played by
adenosine A2A receptors (A2ARs) in Huntington's disease (HD). Since A2ARs are mainly …

Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by
the expansion of a polymorphic CAG trinucleotide repeat encoding a poly-glutamine tract …

Huntington Disease (HD) is characterized by choreic involuntary movements and striatal
vulnerability. A2A receptors expressed on GABAergic striatal neurons have been suggested …

Abstract Adenosine A 1 receptor (A 1 R) stimulation exerts beneficial effects in response to
various insults to the brain and, although it was found neuroprotective in a lesional model of …

Huntington's disease (HD) is an autosomal-dominant degenerative disease caused by a
cytosine-adenine-guanine trinucleotide expansion in the Huntingtin (htt) gene. The most …

Huntington's disease (HD) is an inherited neurodegenerative disorder. Adenosine A2A
receptors (A2ARs) are involved in excitotoxic/neurodegenerative processes, and A2AR …

Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder, the
progression of which cannot be prevented by any neuroprotective approach, despite major …

Huntington's disease (HD) is a devastating hereditary neurodegenerative disorder caused
by a CAG mutation within the IT15 gene encoding huntingtin protein. Even though mutant …

Cognitive impairments in Huntington's disease (HD) are attributed to a dysfunction of the
cortico-striatal pathway and significantly affect the quality of life of the patients, but this has …

Huntington's disease (HD) is a progressive neurodegenerative genetic disorder that leads to
motor, cognitive, and psychiatric disturbances. The primary neuropathological hallmark is …