Cardiac transplantation is the most effective treatment for advanced heart failure. Despite
improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts …

To investigate the functional role of interferon (IFN)-gamma in transplant arteriosclerosis,
BALB/c hearts were transplanted in immunosuppressed C57BL/6J recipients with (n= 10) or …

Accelerated graft arteriosclerosis is an insidious disease, characterized by persistent
perivascular inflammation and myointimal hyperplasia, which occurs in the majority of …

Graft vascular disease (GVD) is the single most important long-term limitation to solid-organ
transplantation. It is a concentric vascular intimal hyperplastic lesion composed of smooth …

Transplant-associated coronary arteriosclerosis is an obstructive, proliferative lesion that
forms in the coronary arteries of transplanted hearts, often within months, and is the most …

Solid organ transplantation is the only treatment for end-stage organ failure but this life-
saving procedure is limited by immune-mediated rejection of most grafts. Blood vessels …

Accelerated graft arteriosclerosis is a major cause of death in human heart transplantation.
Despite many investigations, the pathogenesis of this disease remains undetermined and its …

Allograft arteriopathy is a vascular intimal proliferative process that occurs in all solid organ
transplants and stands as the single most significant obstacle to successful long-term solid …

" Chronic rejection" of allografts may mean different things to different people. Some use this
term to refer to a process more specifically described as arteriosclerotic obstruction of the …

We have hypothesized that T cell cytokines participate in the pathogenesis of graft arterial
disease (GAD). This study tested the consequences of IFN-gamma deficiency on arterial and …