Over the last decade there have been rapid advances in our knowledge about the molecular
basis of many inherited disorders. Molecular testing is now available for many conditions …

Improvements in our understanding of the genetic basis of human disease and increased
utilization of genetic testing have identified a variety of heritable disorders associated with …

Overview: A substantial proportion of childhood cancers are attributable to an underlying
genetic syndrome or inherited susceptibility. Recognition of affected children allows for …

Various cutaneous signs presenting in childhood, for example café‐au‐lait macules, may
have systemic cancer associations. Indeed, this may be the first manifestation of the …

Predisposing genes, environmental factors, and developmental processes are the major
factors that influence cancer risk in children. In the past 2 decades, a large number of genes …

▪ Abstract Clinical cancer genetics is becoming an integral part of the care of cancer patients.
This review describes the clinical aspects, genetics, and clinical genetic management of …

Advances in the understanding of cancer predisposition and implementation of standardized
cancer surveillance protocols have improved the outcome for certain patients. Future …

Abstract Geneticists estimate that 5% to 10% of all cancers diagnosed in the pediatric age
range occur in children born with a genetic mutation that directly increases their lifetime risk …

Inherited cancer syndromes are caused by genetic mutations that place patients at an
increased risk for developing cancer. Although most cancers are not caused by genetic …

Although cancer predisposition syndromes are rare and malignancies arising in this context
account for only 1–10% of childhood tumors, studies performed in affected patients and their …