Polymorphism of the porcine leptin gene promoter and analysis of its association with gene expression and fatness traits

M Stachowiak, M Mackowski, Z Madeja… - Biochemical …, 2007 - Springer
We describe for the first time a 245 bp fragment of the porcine leptin gene promoter in the
proximity of the transcription start site. Altogether, 720 pigs were screened with the PCR …

Genetic polymorphisms in the leptin gene and their association with fatness in four pig breeds

ZH Jiang, JP Gibson - Mammalian Genome, 1999 - search.proquest.com
Fatness in pigs is of economic importance because of market incentives for production of
lean pork and because increasing fatness increases the feed costs of production. Leptin, a …

A new mutation in the coding region of the bovine leptin gene associated with feed intake

R Lagonigro, P Wiener, F Pilla, JA Woolliams… - Animal …, 2003 - Wiley Online Library
An experimental cattle population was screened for polymorphisms in the leptin gene and
five SNPs were found in the regions containing the coding sequences. The association of …

Identification and genetic effects of a novel polymorphism in the distal promoter region of porcine leptin gene

D Liu, Y Hu, X Yang, Y Liu, S Wei, Y Jiang - Molecular biology reports, 2011 - Springer
Leptin is a hormone expressed mainly in white adipose tissue. It acts on satiety centers in
the hypothalamus, and by binding to particular receptor OB-Rb, plays a crucial role in …

Plasma leptin levels in pigs with different leptin and leptin receptor genotypes

M Amills, D Villalba, M Tor, A Mercadé… - Journal of Animal …, 2008 - Wiley Online Library
Summary A C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in
diverse pig breeds yielding controversial results with regard to its association with growth …

Association of a single nucleotide polymorphism in the bovine leptin gene with feed intake, feed efficiency, growth, feeding behaviour, carcass quality and body …

JD Nkrumah, C Li, JB Basarab… - Canadian Journal of …, 2004 - cdnsciencepub.com
Leptin is a 16-kDa-hormone product of the obese gene synthesized and expressed
predominantly by adipose tissues, which has been shown to play major roles in the …

Characterization of swine leptin (LEP) polymorphisms and their association with production traits

YM Kennes, BD Murphy, F Pothier, MF Palin - Animal genetics, 2001 - Wiley Online Library
Four polymorphisms in the swine leptin (LEP) gene were characterized and evaluated for
association with economically important production traits in Yorkshire, Landrace and Duroc …

A missense mutation in the bovine leptin receptor gene is associated with leptin concentrations during late pregnancy

SC Liefers, RF Veerkamp, MFW Te Pas… - Animal …, 2004 - Wiley Online Library
The leptin receptor (LEPR) gene consists of 20 exons divided over 1.75 Mb. Parts of bovine
LEPR exon 4 (79 bp), exon 11 (95 bp) and exon 20 (513 bp) of 20 cows (Holstein‐Friesian) …

Joint effects of porcine leptin and leptin receptor polymorphisms on productivity and quality traits

D Pérez‐Montarelo, A Fernández, JM Folch… - Animal …, 2012 - Wiley Online Library
Leptin signalling plays a fundamental role in growth, fatness and body composition. The aim
of this study was to investigate the porcine LEP gene sequence in an I berian× L andrace …

Genetic polymorphisms in porcine leptin gene and their association with reproduction and production traits

CC Chen, T Chang, HY Su - Australian journal of agricultural …, 2004 - CSIRO Publishing
Leptin (LEP), the product of the leptin gene, is a 16-kDa protein synthesised by adipose
tissue and is involved in regulation of feed intake, energy balance, fertility, and immune …