Adenosine A2A receptor antagonism reverses the effects of dopamine receptor antagonism on instrumental output and effort-related choice in the rat: implications for …
Rationale Organisms frequently make effort-related decisions based upon assessments of
motivational value and response costs. Energy-related dysfunctions such as psychomotor …
motivational value and response costs. Energy-related dysfunctions such as psychomotor …
Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism
EJ Nunes, PA Randall, JL Santerre, AB Given… - Neuroscience, 2010 - Elsevier
Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation and effort-related processes. Rats with impaired DA transmission reallocate their …
activation and effort-related processes. Rats with impaired DA transmission reallocate their …
Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism
JD Salamone, AM Farrar, L Font, V Patel… - Behavioural brain …, 2009 - Elsevier
Adenosine and dopamine receptors in striatal areas interact to regulate a number of different
functions, including aspects of motor control and motivation. Recent studies indicate that …
functions, including aspects of motor control and motivation. Recent studies indicate that …
The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists
LT Worden, M Shahriari, AM Farrar, KS Sink… - …, 2009 - Springer
Rationale Brain dopamine (DA) participates in the modulation of instrumental behavior,
including aspects of behavioral activation and effort-related choice behavior. Rats with …
including aspects of behavioral activation and effort-related choice behavior. Rats with …
The behavioral pharmacology of effort‐related choice behavior: dopamine, adenosine and beyond
For many years, it has been suggested that drugs that interfere with dopamine (DA)
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …
transmission alter the “rewarding” impact of primary reinforcers such as food. Research and …
The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit …
Rationale Mesolimbic dopamine (DA) is a critical component of the brain circuitry regulating
behavioral activation and effort-related processes. Research involving choice tasks has …
behavioral activation and effort-related processes. Research involving choice tasks has …
Dopamine/adenosine interactions involved in effort-related aspects of food motivation
JD Salamone, M Correa - Appetite, 2009 - Elsevier
Nucleus accumbens dopamine (DA) is involved in effort-related aspects of food motivation.
Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort …
Accumbens DA depletions reduce the tendency of rats to work for food, and alter effort …
Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats
Rationale Nucleus accumbens dopamine (DA) participates in the modulation of instrumental
behavior, including aspects of behavioral activation and effort-related choice behavior. Rats …
behavior, including aspects of behavioral activation and effort-related choice behavior. Rats …
Role of dopamine–adenosine interactions in the brain circuitry regulating effort-related decision making: insights into pathological aspects of motivation
Brain dopamine, particularly in the nucleus accumbens, has been implicated in activational
aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce …
aspects of motivation and effort-related processes. Accumbens dopamine depletions reduce …
Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors
AM Farrar, KN Segovia, PA Randall, EJ Nunes… - Neuroscience, 2010 - Elsevier
Nucleus accumbens dopamine (DA) is a critical component of the brain circuitry regulating
work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover …
work output in reinforcement-seeking behavior and effort-related choice behavior. Moreover …