Protein disulfide isomerase (PDI) is involved in isomerization, reduction and oxidation of
disulfide bonds. Recent studies from our lab showed that cell-surface PDI is also involved in …

ABSTRACT PDI (protein disulphide-isomerase) is widely distributed across eukaryotic
tissues, making up approximately 1% of the total protein content of cells. One of the most …

S-Nitrosoglutathione (GSNO) denitrosation activity of recombinant human protein disulfide
isomerase (PDI) has been kinetically characterized by monitoring the loss of the S–NO …

Since thiols can undergo nitrosation and the cell membrane is rich in thiol-containing
proteins, we considered the possibility that membrane surface thiols may regulate cellular …

Abnormal protein accumulations are typical pathological features for neurodegenerative
diseases. Protein disulfide isomerase (PDI) is a critical enzyme in oxidative protein folding. S …

Abstract Nitric oxide (NO•), S-nitrosothiols (RSNO), and cell surface protein disulfide
isomerase (csPDI) are involved in many cellular processes. In this work, we investigate the …

Protein disulfide isomerase (PDI), a homodimer with active sites that contain vicinal dithiols,
catalyzes thiol-disulfide exchange reactions and is found on the cell surface where it is …

N-dansylhomocysteine (DnsHCys) is quenched on S-nitrosation. The product of this
reaction, N-dansyl-S-nitrosohomocysteine, is a sensitive, direct fluorogenic substrate for the …

Protein disulfide isomerase (PDI) is an abundant protein primarily found in the endoplasmic
reticulum and also secreted into the blood by a variety of vascular cells. The evidence …

Abstract Background Nitroarachidonic acid (NO 2 AA) exhibits pleiotropic anti-inflammatory
actions in a variety of cell types. We have recently shown that NO 2 AA inhibits phagocytic …