The lens circulation

RT Mathias, J Kistler, P Donaldson - Journal of Membrane Biology, 2007 - Springer
The lens is the largest organ in the body that lacks a vasculature. The reason is simple:
blood vessels scatter and absorb light while the physiological role of the lens is to be …

Molecular solutions to mammalian lens transparency

P Donaldson, J Kistler, RT Mathias - Physiology, 2001 - journals.physiology.org
The mammalian lens generates an internal microcirculation that maintains transparency in
the avascular lens. Significant progress has been made in characterizing the membrane …

Physiological properties of the normal lens

RT Mathias, JL Rae, GJ Baldo - Physiological reviews, 1997 - journals.physiology.org
The lens is an avascular organ suspended between the aqueous and vitreous humors of the
eye. The cellular structure is symmetric about an axis passing through its anterior and …

Lens biology and biochemistry

JF Hejtmancik, SA Riazuddin, R McGreal, W Liu… - Progress in molecular …, 2015 - Elsevier
The primary function of the lens resides in its transparency and ability to focus light on the
retina. These require both that the lens cells contain high concentrations of densely packed …

Transport properties of the lens

RT Mathias, JL Rae - American Journal of Physiology-Cell …, 1985 - journals.physiology.org
Many studies have shown that the lens is a multicellular syncytial tissue whose
electrophysiological properties are the integrated result of membrane transport, low …

Regulation of lens volume: implications for lens transparency

PJ Donaldson, KSN Chee, JC Lim, KF Webb - Experimental Eye Research, 2009 - Elsevier
Lens transparency is critically dependent on the maintenance of an ordered tissue
architecture, and disruption of this order leads to light scatter and eventually lens cataract …

The lens: local transport and global transparency

RT Mathias, JL Rae - Experimental eye research, 2004 - Elsevier
The perception of the lens changed remarkably during the career of David Maurice. The
early view was that it was an inert sack of protein that assisted the cornea in focusing light on …

The physiological optics of the lens

PJ Donaldson, AC Grey, BM Heilman, JC Lim… - Progress in retinal and …, 2017 - Elsevier
The optical properties of the ocular lens are important to overall vision quality. As a
transparent biological tissue, the lens contributes to the overall and dynamic focussing …

Transport of fluid by lens epithelium

J Fischbarg, FPJ Diecke, K Kuang… - … of Physiology-Cell …, 1999 - journals.physiology.org
We report for the first time that cultured lens epithelial cell layers and rabbit lenses in vitro
transport fluid. Layers of the αTN4 mouse cell line and bovine cell cultures were grown to …

Identity and regulation of ion transport mechanisms in the corneal endothelium

JA Bonanno - Progress in retinal and eye research, 2003 - Elsevier
Corneal transparency is dependent on regulation of the hydration of the corneal stroma.
Water is driven into the cornea across the epithelial and endothelial cell layers by the …