The three Tritryps, the pathogenic protozoa, Leishmania major, Trypanosoma brucei and
Trypanosoma cruzi use surface molecules among others to evolve strategies for evading the …

The life cycle of Leishmania alternates between developmental forms residing within the
insect vector (eg promastigotes) and the mammalian host (amastigotes). In Leishmania …

New formulations and therapeutic switching of the established drugs, amphotericin B and
paromomycin, together with the discovery of miltefosine, have significantly improved the …

Gene expression in Trypanosomatids requires processing of polycistronic transcripts to
generate monocistronic mRNAs by cleavage events that are coupled to the addition of a …

Background Leishmania and other members of the Trypanosomatidae family diverged early
on in eukaryotic evolution and consequently display unique cellular properties. Their …

Background Whole genome studies have highlighted duplicated genes as important
substrates for adaptive evolution. We have investigated adaptive evolution in this class of …

Background Trypanosoma brucei is the causative agent of human sleeping sickness and
animal trypanosomiasis in sub-Saharan Africa, and it has been subdivided into three …

The actin cytoskeleton controls pivotal cellular processes such as motility and cytokinesis, as
well as cell-cell and cell-substrate interactions. Assembly and spatial organization of actin …

Background Trypanosoma cruzi, a flagellate protozoan, is the etiological agent of Chagas
disease, a chronic illness that causes irreversible damage to heart and digestive tract in …

The Structural Genomics of Pathogenic Protozoa (SGPP) Consortium aimed to determine
crystal structures of proteins from trypanosomatid and malaria parasites in a high throughput …