Cytokine expression in the inflamed synovial membrane of patients with rheumatoid arthritis
and other forms of chronic inflammatory arthritis and other forms of chronic inflammatory …

Anti-tumour necrosis factor (TNF) agents have revolutionized the treatment of patients with
rheumatoid arthritis (RA). These therapies are, however, expensive and 30% of patients fail …

Tumor necrosis factor-alpha (TNF-α) is a vital component of the inflammatory process and its
aberrant over-expression has been linked to numerous disease states. New treatment …

Background: Treatment of rheumatoid arthritis (RA) has shifted toward earlier and more
aggressive therapy with traditional disease-modifying antirheumatic drugs (DMARDs) and …

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of
the articular synovium, resulting in bony erosions, deformity, and, ultimately, joint …

Inflammation is the major factor driving the progression of structural damage in rheumatoid
arthritis (RA); therefore, it is critical to achieve rapid suppression of inflammation to maximize …

TNF is an exciting cytokine which has helped to establish many paradigms in immunology.
Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which …

Background: IL-1 receptor antagonist (IL-1Ra) is a naturally occurring IL-1RI-binding
molecule that blocks the biologic effects of the proinflammatory cytokine IL-1. A recombinant …

Objective: To study the prevalence of orthopaedic surgery and to evaluate possible
predictive factors for large joint replacements in patients with early rheumatoid arthritis (RA) …

Objective: To report adverse events (AEs) seen in a large cohort of patients with juvenile
idiopathic arthritis (JIA) treated with tumour necrosis factor (TNF) α blockers (infliximab and …