Treatment-related improvement in physical function varies with duration of rheumatoid arthritis: a pooled analysis of clinical trial results
D Aletaha, V Strand, JS Smolen… - Annals of the Rheumatic …, 2008 - ard.bmj.com
Background: Physical function in rheumatoid arthritis (RA) has reversible and irreversible
components, and is typically assessed by the Health Assessment Questionnaire Disability …
components, and is typically assessed by the Health Assessment Questionnaire Disability …
Activation of peroxisome proliferator-activated receptor γ inhibits TNF-α-mediated osteoclast differentiation in human peripheral monocytes in part via suppression of …
H Hounoki, E Sugiyama, SGK Mohamed, K Shinoda… - Bone, 2008 - Elsevier
Tumor necrosis factor-α (TNF-α) plays critical roles in bone resorption at the site of
inflammatory joints. The aim of this study is to evaluate the effect of peroxisome proliferator …
inflammatory joints. The aim of this study is to evaluate the effect of peroxisome proliferator …
Effects of switching between anti-TNF therapies on HAQ response in patients who do not respond to their first anti-TNF drug
Objectives. Small studies have shown an improvement in disease activity in patients with RA
who have switched between anti-TNF therapies for reasons of inefficacy. However, it is not …
who have switched between anti-TNF therapies for reasons of inefficacy. However, it is not …
Molecular targets of rheumatoid arthritis
H Okamoto, D Hoshi, A Kiire… - … & Allergy-Drug …, 2008 - ingentaconnect.com
Rheumatoid arthritis (RA) is a multifactorial disease characterized by chronic inflammation of
the joints. Both genetic and environmental factors are involved in the pathogenesis of joint …
the joints. Both genetic and environmental factors are involved in the pathogenesis of joint …
Synergistic immunosuppressive effect of anti-TNF combined with methotrexate on antibody responses to the 23 valent pneumococcal polysaccharide vaccine
LBS Gelinck, AE Van Der Bijl, LG Visser, TWJ Huizinga… - Vaccine, 2008 - Elsevier
INTRODUCTION: The efficacy of the immune response upon vaccination in patients treated
with anti-tumor necrosis factor-alpha (anti-TNF) with or without methotrexate is the subject of …
with anti-tumor necrosis factor-alpha (anti-TNF) with or without methotrexate is the subject of …
A novel formulation of inhaled doxycycline reduces allergen-induced inflammation, hyperresponsiveness and remodeling by matrix metalloproteinases and cytokines …
MM Gueders, P Bertholet, F Perin, N Rocks… - Biochemical …, 2008 - Elsevier
BACKGROUND: In this study, we assess the effectiveness of inhaled doxycycline, a
tetracycline antibiotic displaying matrix metalloproteinases (MMP) inhibitory effects to …
tetracycline antibiotic displaying matrix metalloproteinases (MMP) inhibitory effects to …
Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-α, and CXCL-1
Endothelins (ETs) are involved in inflammatory events, including pain, fever, edema, and
cell migration. ET-1 levels are increased in plasma and synovial membrane of rheumatoid …
cell migration. ET-1 levels are increased in plasma and synovial membrane of rheumatoid …
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and …
Z Lu, GR Ott, R Anand, RQ Liu, MB Covington… - Bioorganic & medicinal …, 2008 - Elsevier
Potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) were
discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino …
discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino …
Treatment of collagen‐induced arthritis with an anti‐osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells
K Fan, J Dai, H Wang, H Wei, Z Cao… - … : Official Journal of …, 2008 - Wiley Online Library
Objective To test the effects of a novel monoclonal antibody (mAb) against human
osteopontin (OPN) in the prevention and treatment of collagen‐induced arthritis (CIA) and to …
osteopontin (OPN) in the prevention and treatment of collagen‐induced arthritis (CIA) and to …
Relationship of serum TWEAK level to cytokine level, disease activity, and response to anti‐TNF treatment in patients with rheumatoid arthritis
MC Park, SJ Jung, YB Park, SK Lee - Scandinavian journal of …, 2008 - Taylor & Francis
Objectives: To determine the serum concentration of tumour necrosis factor (TNF)‐related
weak inducer of apoptosis (TWEAK) in patients with rheumatoid arthritis (RA) and to …
weak inducer of apoptosis (TWEAK) in patients with rheumatoid arthritis (RA) and to …