Fibroblast growth factor-21 as a therapeutic agent for metabolic diseases
A Kharitonenkov, AB Shanafelt - BioDrugs, 2008 - Springer
Abstract Fibroblast growth factor (FGF)-21 is a unique member of the FGF family, with
several molecular characteristics that differ from classical FGFs and exhibiting a …
several molecular characteristics that differ from classical FGFs and exhibiting a …
Mini-review: endocrine actions of fibroblast growth factor 19
S Jones - Molecular pharmaceutics, 2008 - ACS Publications
Fibroblast growth factor (FGF) 19 is an atypical member of the fibroblast growth factor family
of signaling molecules. FGF19, FGF21, and FGF23 comprise a phylogenetic subfamily with …
of signaling molecules. FGF19, FGF21, and FGF23 comprise a phylogenetic subfamily with …
C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors
X Wu, B Lemon, XF Li, J Gupte, J Weiszmann… - Journal of Biological …, 2008 - ASBMB
FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast
growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin …
growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin …
β-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
J Sinha, F Chen, T Miloh, RC Burns… - American Journal …, 2008 - journals.physiology.org
β-Klotho, a newly described membrane protein, regulates bile acid synthesis. Fibroblast
growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar …
growth factor-15 (FGF-15) and FGF receptor-4 (FGFR4) knockout mice share a similar …
[HTML][HTML] Does Fgf23–klotho activity influence vascular and soft tissue calcification through regulating mineral ion metabolism?
F Memon, M El-Abbadi, T Nakatani, T Taguchi… - Kidney international, 2008 - Elsevier
Recent studies describe a novel role of fibroblast growth factor-23 (Fgf23)–klotho activity in
the systemic regulation of calcium and phosphate homeostasis. Both Fgf23 and klotho …
the systemic regulation of calcium and phosphate homeostasis. Both Fgf23 and klotho …
The Klotho gene family and the endocrine fibroblast growth factors
H Kurosu, M Kuro-o - Current opinion in nephrology and …, 2008 - journals.lww.com
Recent mouse genetic studies have broadened our understanding of molecular pathways
involved in mineral and bile acid homeostasis regulated by FGF23 and FGF19, respectively …
involved in mineral and bile acid homeostasis regulated by FGF23 and FGF19, respectively …
Molecular genetic and biochemical analyses of FGF23 mutations in familial tumoral calcinosis
HJ Garringer, M Malekpour… - American Journal …, 2008 - journals.physiology.org
Fibroblast growth factor 23 (FGF23) is a hormone required for normal renal phosphate
reabsorption. FGF23 gain-of-function mutations result in autosomal dominant …
reabsorption. FGF23 gain-of-function mutations result in autosomal dominant …
Klotho and Na+,K+-ATPase activity: solving the calcium metabolism dilemma?
MS Razzaque - Nephrology Dialysis Transplantation, 2008 - academic.oup.com
Despite the widely known fact that low concentrations of extracellular free calcium can
induce parathyroid hormone (PTH) secretion, the molecular mechanisms of such regulation …
induce parathyroid hormone (PTH) secretion, the molecular mechanisms of such regulation …
Beyond cholesterol lowering: pleiotropic effects of bile acid binding resins against cardiovascular disease risk factors in patients with metabolic syndrome
M Yamaoka-Tojo, T Tojo, T Izumi - Current vascular …, 2008 - ingentaconnect.com
Prospective epidemiologic studies have shown that dyslipidemia and hyperglycemia are
major risk factors for atherosclerotic cardiovascular diseases. Undesirable metabolic …
major risk factors for atherosclerotic cardiovascular diseases. Undesirable metabolic …
Genetic suppression of GH-IGF-1 activity, combined with lifelong caloric restriction, prevents age-related renal damage and prolongs the life span in rats
Y Zha, T Taguchi, A Nazneen, I Shimokawa… - American journal of …, 2008 - karger.com
Aim: The aim of this study was to determine the effects of kidney pathology on overall
survival and longevity and the combined effects of chronic suppression of growth hormone …
survival and longevity and the combined effects of chronic suppression of growth hormone …