Frequency and fate of microRNA editing in human brain
Primary transcripts of certain microRNA (miRNA) genes (pri-miRNAs) are subject to RNA
editing that converts adenosine to inosine (A→ I RNA editing). However, the frequency of the …
editing that converts adenosine to inosine (A→ I RNA editing). However, the frequency of the …
MicroRNAs flex their muscles
MicroRNAs negatively regulate gene expression by promoting mRNA degradation and
inhibiting mRNA translation. Recent studies have uncovered a cadre of muscle-specific …
inhibiting mRNA translation. Recent studies have uncovered a cadre of muscle-specific …
MicroRNAs: novel regulators in cardiac development and disease
MicroRNAs (miRNAs) are endogenous, small ribonucleotides regulating the translation of
target messenger RNAs that have been shown to be involved in orchestrating growth …
target messenger RNAs that have been shown to be involved in orchestrating growth …
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
Dicer initiates RNA interference by generating small RNAs involved in various silencing
pathways. Dicer participates in centromeric silencing, but its role in the epigenetic regulation …
pathways. Dicer participates in centromeric silencing, but its role in the epigenetic regulation …
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
SJ Harvey, G Jarad, J Cunningham… - Journal of the …, 2008 - journals.lww.com
MicroRNAs (miRNAs) regulate gene expression by binding the 3′ untranslated region of
mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in …
mRNAs. To define their role in glomerular function, miRNA biogenesis was disrupted in …
Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D
MICA and MICB are stress-induced ligands recognized by the activating receptor NKG2D. A
microRNA encoded by human cytomegalovirus downregulates MICB expression by …
microRNA encoded by human cytomegalovirus downregulates MICB expression by …
MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries
M Bar, SK Wyman, BR Fritz, J Qi, KS Garg… - Stem …, 2008 - academic.oup.com
We used massively parallel pyrosequencing to discover and characterize microRNAs
(miRNAs) expressed in human embryonic stem cells (hESC). Sequencing of small RNA …
(miRNAs) expressed in human embryonic stem cells (hESC). Sequencing of small RNA …
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury
J Ho, KH Ng, S Rosen, A Dostal… - Journal of the …, 2008 - journals.lww.com
MicroRNAs (miRNAs) are in a class of endogenous, small, noncoding RNAs that exert their
effects through posttranscriptional repression of specific target mRNAs. Although miRNAs …
effects through posttranscriptional repression of specific target mRNAs. Although miRNAs …
A diverse set of microRNAs and microRNA-like small RNAs in developing rice grains
QH Zhu, A Spriggs, L Matthew, L Fan… - Genome …, 2008 - genome.cshlp.org
Endogenous small RNAs, including microRNAs (miRNAs) and short-interfering RNAs
(siRNAs), function as post-transcriptional or transcriptional regulators in plants. miRNA …
(siRNAs), function as post-transcriptional or transcriptional regulators in plants. miRNA …
Elevated expression of the miR-17–92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotype
E Connolly, M Melegari, P Landgraf… - The American journal of …, 2008 - Elsevier
Alterations in microRNA (miRNA) expression in both human and animal models have been
linked to many forms of cancer. Such miRNAs, which act directly as repressors of gene …
linked to many forms of cancer. Such miRNAs, which act directly as repressors of gene …